Gina Trapani:

Portable applications and creative uses for USB drives and other external hard drives have come a long way in the last year or so. Today I’ll go over some of the more practical uses and techniques for managing your data on the go with a portable drive.

My first impression? Cool! But, god help you if you lose that thing. She does include a link to a VB script that will remind you, on screen, to remove the drive when you are logging off and shutting down.